Professor Michael Davies

Position

Deputy Director of The Heart Research Institute in Sydney, and a Conjoint Professor of the University of Sydney.

Qualifications
•    ARC QE2 fellowship (1995) and Group Leader position at The Heart Research Institute.
•    University of York Chemistry Department staff member.
•    Postdoctoral studies (1984–1987) Brunel University London with Professors Trevor Slater and Robin Willson.
•    PhD (1984) University of York, UK working with Professors Richard Norman and Bruce Gilbert.
•    Fellow of the Royal Australian Chemical Institute.

Expertise
•    Free radical chemistry and biology, ranging from molecular modeling, through mechanistic and kinetic studies, to studies on intact biological samples.

Key Areas of Research

•    Protein hydroperoxides and radical chain reactions in protein damage.
•    Role of myeloperoxidase-derived oxidants in biological damage.
•    Iron and copper as catalysts of radical damage in the artery wall.
•    Nitric oxide and nitroxides as potential inhibitors of protein damage.
•    Role of photo-oxidation in cellular damage and human disease.
•    Determining kinetic and mechanistic data for oxidation reactions on proteins.
•    Peroxynitrite and reactive nitrogen species in atherosclerosis.
•    Role of radical reactions in protein modification.
•    Development of novel markers for radical damage in biological systems.

Selected Publications

Lund, ML., Luxford, C., Skibsted, LH; Davies, MJ Biochem. J. 2008, 410, 565-574.

Mizdrak, J.; Hains, PG; Truscott, RJW; Jamie, JF; Davies, MJ. Free Radic. Biol. Med. 2008, 44, 1108-1119.