Professor Carl Schiesser

Position

Professor of Chemistry in the School of Chemistry at the University of Melbourne and Director of the ARC Centre of Excellence for Free Radical Chemistry and Biotechnology.

Qualifications

• DSc (2000) University of Adelaide.
• Postdoctoral studies (1988–1990) University College London with Professor Alwyn Davies.
• PhD (1987) the Australian National University working with Professor Athel Beckwith.
• Fellow of the Royal Australian Chemical Institute, and the Royal Society of Chemistry.

Expertise

• Free radical chemistry,
• Molecular modeling of radical reactions,
• Mechanistic and kinetic studies of radical reactions,
• Development of new chemical methodology and synthesis.

Key Areas of Research

• Design, synthesis and evaluation of novel antioxidant antihypertensives.
• Multi-orbital interactions in radical chemistry.
• Controlling biodeterioration of culturally significant materials.
• Understanding and improving the action of isoniazid in tuberculosis treatment.
• Synthesis and evaluation of novel, dual-acting, cardioprotective agents.
• Determining absolute kinetic data for free radical reactions at selenium.
• Development of novel chiral stannanes for use in synthesis.
• Design and synthesis of new bioreductive prodrugs as tumour selective cytotoxins.
• Development of new, tandem free radical synthetic methodology.

Selected Publications

Grange, RL; Ziogas, J; North, AJ; Angus, JA; Schiesser, CH. Selenosartans: Novel Selenium–Containing Compounds with Antihypertensive Activity. Bioorg. Med. Chem. Lett., 2008, 18, 1241 – 1244.

Amos, RIJ; Gourlay, BS; Schiesser, CH; Smith, JA; Yates, BF. A Mechanism on the Oxidation of Hydrazides: Application to the Tuberculosis Drug Isoniazid, Chem. Commun., 2008, 1695 – 1697.